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ABANTEL® 520 mg (abamectin, closantel) for treatment of Fasciolosis nematodoses, estrous, scabies in sheep. 10 boluses

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ABANTEL® 520 mg (abamectin, closantel) for treatment of Fasciolosis nematodoses, estrous, scabies in sheep. 10 boluses

ABANTEL for treatment of fascioliasis; nematodiasis parasites in small ruminants; oestrosis in sheep; Melophagus infestation in sheep; hypodermiasis in goats; scabies (mange) in sheep; invasions with pasture ticks. 10 boluses

 

 

 

1. NAME  OF THE MARKETING AUTHORISATION HOLDER

 

Name: Biovet

 

2. NAME OF THE VETERINARY MEDICINAL PRODUCT

ABANTEL

 

 

 

 

ABANTEL® 520 mg

(abamectin, closantel)

COMPOSITION

One bolus contains:

 

Abantel 520 mg

Abamectin

20 mg

Closantel sodium, equivalent to closantel

500 mg

Excipients

up to 5 g

PHARMACOLOGICAL ACTION

Abamectin is an avermectin endectocide inducing an anthelmintic (antinematodal) effect on endoparasites and antiarthropodal (insecticidal and acaricidal - against parasitizing insects and ticks) effect on ectoparasites in small ruminants.

Abamectin stimulates the release of gamma-aminobutyric acid (GABA), which suppresses the transmission of nerve impulses, as a result of which paralysis and death of nematodes, insects and ticks occur. It does not pass through the blood-brain barrier in warm-blooded animals. Closantel sodium is a salicylanilide derivative. It can also be assigned to the group of endectocides because it exerts anthelmintic (antitrematodal and antinematodal), and antiarthropodal (insecticidal and acaricidal on parasitizing insects) effect on endo- and ectoparasites in small ruminants. The mechanism of its action on Fasciola spp. is based on interruption of oxidative phosphorylation with suppression of the activity of succinate dehydrogenase and fumarate reductase. It binds to plasma albumins and is excreted slowly in bile. It exerts a long-lasting protective effect on sheep (up to 30-40 days against Ostertagia spp. and Haemonchus spp.). The combination of abamectin and closantel induces a stronger and wider antiparasitic effect on Trematodes (liver fluke) - Fasciola hepatica, F. gigantica (adult forms - 97-100%; larval forms - 6- to 8-week - 91-95%; larval - 5-week - 91%); on gastrointestinal and lung Nematodes (lungworms) - blood-sucking Haemonchus contortus, Ostertagia circumcincta (including their inhibited larval stage); on their benzimidazole-resistant strains; on Chabertia ovina, Strongyloides papillosus, Trichostrongylus axei, T. colubriformis (adult forms), Cooperia annulata, Oesophagostomum dentatum, O. columbianum, Nematodirus spathiger, N. filicollis, Trichuris ovis, Dictyocaulus filaria (adult forms and fourth stage larvae), Protostrongylus rufescens (adult forms). It also reveals an antinematodal activity against Cystocaulus ocreatus and Muellerius capillaris. It induces insecticidal effect against warbles -Oestrus ovis (all larval stages), Hypoderma silenus (Przhevalskiana silena - in goats), against sheep ked - Melophagus ovinus, as well as acaricidal effect in invasions of pasture ticks and mange mites - Psoroptes ovis, Ixodes ricinus, Rhipicephalus sanguineus, Dermacentor reticulatus. The product is well tolerated by sheep and goats, pregnant animals included. In case of overdosage depression, disturbed gait and mydriasis may occur.

INDICATIONS

For treatment of fascioliasis; nematodiasis caused by the above mentioned parasites in small ruminants; oestrosis in sheep; Melophagus infestation in sheep; hypodermiasis in goats; scabies (mange) in sheep; invasions with pasture ticks.

CONTRAINDICATIONS

Not established.

MODE OF ADMINISTRATION (Rp)

Orally, by means of an applicator (supplied in the package).

TARGET SPECIES

Sheep and goats.

DOSAGE

Sheep and goats - one bolus per 50 kg b.w.

In case of Cystocaulus and Muellerius infestation in sheep - two boli per 50 kg b.w.

Administer the product in spring (before taking the animals out to graze) and in autumn.

SIDE EFFECTS

Not established.

WITHDRAWAL PERIOD

For meat - 21 days from the last administration of the preparation. For milk - 7 days from the last administration of the preparation.

PACKAGING

A box of 1 blister with 10 boli each.

WARNING

Do not apply simultaneously with chlororganic compounds.

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