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Gentamicin 10% Solution for injection (gentamicin sulphate) 100ml

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Gentamicin 10% Solution for injection (gentamicin sulphate) 100ml

Gentamicin 10% Solution for injection

(gentamicin sulphate) 100ml

 

 

 

1. NAME  OF THE MARKETING AUTHORISATION HOLDER

Name: Biovet

2. NAME OF THE VETERINARY MEDICINAL PRODUCT

Gentamicin 10%  

 

 

 COMPOSITION

 

Content

Gentamicin 4% Solution for injection

 

Gentamicin 10% Solution for injection

Gentamicin sulphate, equivalent to gentamicin base

 0.04 g

0.1 g

Excipients

Up to 1 ml

Up to 1 ml

 

PHARMACOLOGICAL ACTION

Gentamicin is an aminoglycoside antibiotic with a bacteriocidal static effect mainly against Gram-negative microorganisms: E.coli, Salmonella spp., Klebsiella spp., Shigella spp., a number of Proteus and Pseudomonas strains, some Gram-positive microorganisms such as: Staphylo­cocci, beta-hemolytic Streptococci and Corynebacteria spp, as well as Mycoplasma spp.

It is quickly absorbed from the injection site and is retained in the blood and tissues for 12-24 h. It is eliminated unchanged in the urine, where its concentration significantly exceeds that in the blood.

 

INDICATIONS

For treatment of respiratory, gastrointestinal and urogenital infections (bronchitis, pneumonia, pyelonephritis, cystitis, urethritis, endometritis, colibacillosis, salmonellosis, infected wounds, pyodermia sepsis, etc.), caused by gentamicin-sensitive microorganisms.

 

CONTRAINDICATIONS

 

 In cases of continuous administration in higher doses the preparation may cause heavy nephritis and damages of the vestibular and hearing organs, especially in cats. If ataxia and vomiting occur, the treatment must be terminated.

 

MODE OF ADMINISTRATION

 

Intramuscularly, subcutaneously, orally and intrauterinally.

 

TARGET SPECIES

 

Ruminants, horses, pigs, chickens, dogs and cats.

 

DOSAGE

Intramuscularly

 

 

Species

 

Gentamicin 4% Solution for injection, mg/ kg b.w.

 

Gentamicin 4% Solution for injection, ml/ 100 kg b.w.

 

Gentamicin 10% Solution for injection, mg/ kg b.w.

 

Gentamicin 10% Solution for injection, ml/ 100 kg b.w.

Ruminant, horses

2 – 4

5 – 10

2 – 4

2 – 4

Pigs

5

12.5

5

0.5

Dogs and cats

4 – 6

1.0 – 1.5

4 – 6

0.4 – 0.6

 

On the first day, the dose must be injected twice at a 12-hour interval. Subsequently, Gentamicin 4% and Gentamicin 10% are administered once per day for not more than 7 consecutive days.

Orally, with the drinking water

In chickens of older age - Use 2.5 ml of Gentamicin 4% and 1 ml of Gentamicin 10% for litter drinking water in the course of 4-5 days.

 

Subcutaneously

In chickens (for control of colibacillosis and paratyphus) the preparation is diluted with sterile distilled water (1:40) for Gentamicin 4% and (1:100) for Gentamicin 10% and is injected at a dose rate of 0.2 ml/1-day-old chicken.

Intrauterinally

In cows (for treatment of endometritis) 5.0 ml of Gentamicin 4% and 2.0 ml of Gentamicin 10% is diluted with 20-50 ml isotonic solution of sodium chloride.

In mares 12.5 ml of Gentamicin 4% and 5.0 ml of Gentamicin 10% diluted with 200 ml isotonic solution of sodium chloride.

In case of pyometra the exudate must be preliminarily removed.

 

SIDE EFFECTS

Severe renal disorders accompanied by azotemia.

Do not apply simultaneously with general anesthetics, muscle relaxants, other aminoglycosides, polymyxins.

 

WITHDRAWAL PERIOD

For meat (excluding kidneys and injection site) – 7 days after the last administration of the prepa­ration.

For kidneys and injection site – 45 days after the last administration of the preparation.

For milk – 2 days after the last administration of the preparation.

 

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight.

 

PACKING

Multidose vials of 100 ml.

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