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TRISULFIN tablets Sulfamethoxazole/ Trimethoprim

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TRISULFIN tablets Sulfamethoxazole/ Trimethoprim

TRISULFIN tablets

Sulfamethoxazole/ Trimethoprim

 

 

 

1. NAME  OF THE MARKETING AUTHORISATION HOLDER

 Name: Balkanpharma

 

2. NAME OF THE VETERINARY MEDICINAL PRODUCT

TRISULFIN

 

 

Contain:

Each tablet contains: Sulfamethoxazole 400 mg, trimethoprim 80 mg and excipients to 600 mg.  Available in packs of  20 tablets, packed blisters containing 10  tablets..

 

Mode of action:
In combination, the two active constituents have a bactericidal activity against most gram-positive and gram-negative pathogenic bacteria.  The combination acts by inhibiting sequential steps in the biosynthetic pathway that is used by micro-organisms in their synthesis of folate cofactors.  Sulphadiazine inhibits the incorporation of para-aminobenzoic acid (PABA) into folic acid and Trimethoprim inhibits the enzyme dihydrofolate reductase, which converts dihydrofolic acid into tetrahydrofolic acid.

 

Indications:
For treatment of infections of the respiratory tract, urogenital tract and alimentary tract, the gallbladder and biliary tract, skin, soft tissue and bone, general septicemic conditions, toxoplasmosis, coccidiosis and other diseases in dogs and cats, caused by sulphadiazine / trimethoprim-sensitive micro-organisms and protozоа.

 

Contraindications:

Do not use in animals with a hypersensitivity to sulfonamides, trimethoprim, or to any of the excipients. Do not use in animals with severe hepatic or renal impairment

 and impairment  to the hematopoietic system, in pregnant and lactating dogs and cats.

 

Adverse reactions:

Although rare in dogs are possible crystalluria, gastrointestinal disorders (loss appetite, vomiting, diarrhea, disbacteriosis) and skin symptoms (redness, rash, pruritus, photosensitivity, swelling of the face). Very rarely with prolonged use registered transient hematological changes (aplastic anemia, leukopenia, thrombocytopenia, methemoglobinemia), keratoconjunctivitis sicca, fever, hypothyroidism, polyarthritis. In  cats were observed anorexia, anemia and leukopenia.

 

Medicine or other forms of interaction

The sulfamethoxazole  and trimethoprim can increase serum levels and increase the effects of coumarin anticoagulants , phenylbutazone , indomethacin , salicylates, probenecid, oral antidiabetics with sulfonylurea structure , thiazide diuretics, phenytoin. Antacids reduce absorption of sulfamethoxazole from the alimentary canal and  urotropin increases crystalluria .

Local anesthetics from the group of esters of para-aminobenzoic acid ( procaine, anestezin , dikain ) reduce the activity of the sulfonamides .

Directions for use:
FOR ORAL USE ONLY.

For cats and dogs

For veterinary use only

Dosage:

General Dose Rate 

30mg of combined active constituents per kg bodyweight every 12 hours for  7-10 days (1 tablet daily per 8kg bodyweight).

In nocardiosis dose is doubled.

In toxoplasmosis and neosporosis dose is 15 mg / kg bodyweight every 12 hours for 2 - 4 weeks.

In coccidiosis in dogs, the dose is 30 mg / kg bodyweight  once per day for 10 days and in  pneumocystosis - 15 mg / kg bodyweight  every 8 hours  or 30 mg / kg bodyweight  every 12 hours  for 3 weeks.

If it necessary, the treatment can be combined with antibiotics. During treatment, the dogs and cats to keep of appropriate water regime.

Storage:
Store below 25°C (room temperature).

Keep out of reach of children

 

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