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TYLOVET® Pulvis water-soluble for pigeons, chickens, turkeys, pigs, and calves (tylosin tartrate 500 mg/g ) 10 g

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TYLOVET®

Pulvis water-soluble for pigeons, chickens, turkeys, pigs, and calves

(tylosin tartrate 500 mg/g ) 10 g

TYLOVET®

Pulvis water-soluble for pigeons, chickens, turkeys, pigs, and calves

(tylosin tartrate 500 mg/g )

 

 

 

1. NAME  OF THE MARKETING AUTHORISATION HOLDER

Name: Biovet

2. NAME OF THE VETERINARY MEDICINAL PRODUCT

Tylovet

 

PACKING

Plastic bottles of 10g.

 

 COMPOSITION

 

Content

 

Tylovet® Pulvis water-soluble

 

Tylosin tartrate, equivalent to tylosin base

 

50 g

 

Excipients

 

up to 100 g

 

PHARMACOLOGICAL ACTION

Tylosin is a macrolide antibiotic with a bacteriostatic effect (inhibiting the synthesis of the bacterial proteins) against Gram-positive microorganisms – Staphylococcus spp., Streptococcus spp., Erysipelotrix spp., Gram-negative microorganisms: Diplococcus spp., Serpulina spp., Treponema hyodysenteriae, Leptospira spp, Fusobacterium spp., Bacteroides spp. (anaerobic microorganisms), Campylobacter (Vibrio) coli, as well as some Rickettsia and Chlamydia spp. Of particular importance is the activity of tylosin against Mycoplasma spp. (it excels in efficacy a large number of chemotherapeutic agents). The antimycoplasmal activity of tylosin is potentiated in combination with tetracyclines, with spectinomycin (in concentrations 3 times lower than the respective therapeutic ones – in vitro and in vivo). Tylosin does not act antimicrobially directly on the bacteria of the family Enterobacteriaceae E. coli, Salmonella spp., but reveals an anti-adhesive activity (hindering their adhesion on the intestinal villi, their penetration through the intestinal mucous membrane and impeding their colonization’s phase as well). Tylosin proves also an anticoccidial activity mostly against Eimeria tenella. Applied orally, the antibiotic is quickly absorbed and maintains bacteriostatic concentrations in the blood and the target tissues, especially in the lungs, the liver, the kidney for 8-12 h. When given with the drinking water in the recommended dosage schedule, its blood concentrations are over the minimal bacteriostatic ones and are kept during the time of administration. Its absorption is increased in combination with the mucolytic agent bromhexine. Its excretion is mainly through the urine and the bile, the milk (in lactating animals) and the eggs (in egg-producing fowls). Tylosin increases the cellular immunity in chickens. Its influence on T-lymphocytes and B-lymphocytes is relatively short (about 3 days). Tylosin is compatible with tetracyclines, sulphonamides, erythromycin and spectinomycin. Its solution is sensitive to light (disintegration occurs) and stable to high temperature.

INDICATIONS

For prevention and treatment of infections caused by tylosin-susceptible pathogenic microorganisms – respiratory mycoplasmosis/chronic respiratory disease in chickens and turkeys; infectious synovitis and sinusitis in turkeys; Borreliosis (Spirochetosis) in fowls and turkeys; Necrotic Enteritis and Infectious Coryza in poultry; Dysentery and Necrotic Enteritis in pigs.

CONTRAINDICATIONS

Do not administer to rabbits, guinea pigs and hamsters.

MODE OF ADMINISTRATION

The recommended dose of Pharmasin®/ Tylovet® pulvis water-soluble is necessary to be dissolved in a small quantity of drinking water pouring the water to the preparation (not vice versa). Then the solution thus prepared must be diluted to the desired concentration. The watering troughs must be placed away from direct sunlight.

 

TARGET SPECIES

Chickens, pigeons (racing), turkeys, pigs, and calves.

DOSAGE

For preventive treatment:

fowls – 1.0 g of the preparation (= 0.5 g or 500 000 IU tylosin base) per 1 l of drinking water following the schedule below:

 

 

Species

Age

Duration of treatment (days)

Chickens for fattening

1st day

28th day

3

1

Growing commercial layers (Replacement pullets)

1st day

3rd week

9th week, 16th week

3

1

2

Growing breeder layers

1st day 4th, 9th, 16th, 20th, 24th week

5

2

Turkeys for fattening

1st day

4th week

5

1

 

For therapeutic treatment:

Fowls – the same dose of the preparation in the course of 2–5 days depending on the severity of the disease or as per the following scheme: for chickens – 4 days; for pullets – 8 days, for hens – 15 days; for turkeys – 5 days

Pigs – 0.5 g (250 000 IU) per 1-2 l water for 3 to 5 days (the treatment should be carried out at least 24 hours after diarrhea has stopped). Swine which cannot take water or vomit should be treated i.m. with Pharmasin®/ Tylovet® B-50 or Pharmasin®/ Tylovet® B-200 after which the treatment should be prolonged with Pharmasin®/ Tylovet® 10% premix at a dose of 100.0 g/ ton feed (with respect to pure tylosin) in the course of 21 days.

SIDE EFFECTS

In pigs, rarely, erythema, itching of the area around the anus and large intestine prolapse can appear. These signs disappear after the end of the treatment and no special medication is needed.

WITHDRAWAL PERIOD

For meat – 3 days after the last administration of the preparation.

STORAGE

In the original packing, well closed, in dry and well-ventilated facilities, protected from direct sunlight.

PACKING

Plastic bottles of 10g. 

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